Case/Lecture one: Hemoglobin Synthesis by Joselito R. Tumulak Jr., MS (cand.) - Professor of Biochemistry
One. Review about the structure of hemoglobin
Three. How do we synthesize hemoglobin
Where do we see hemoglobin?
Types and Structure of Hemoglobin
Major forms of hemoglobin in adults:
Allosteric Behavior and Positive Cooperativity
Hemoglobin Synthesis Requirements:
FIRST STEP OF HEME SYNTHESIS
STRUCTURE OF PORPHOBILINOGEN
FORMATION OF UROPORPHYRINOGEN
· REVIEW ON PROTEIN SYNTHESIS:
DNA, GENES, AND TRANSLATION OF GLOBINS
CHROMOSOMAL LOCATION OF GLOBIN GENES
TWO MAJOR TYPES OF ADULT GLOBINS
COMBINING HEME AND GLOBIN
SUMMARY OF HEMOGLOBIN SYNTHESIS
REGULATORS OF HEMOGLOBIN SYNTHESIS
One. Systemic regulators:
Two. Metabolic cofactors: