Pharmacological Interventions for Alcohol Use Disorder

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CHAPTER Sixty Pharmacological Interventions for Alcohol Use Disorder Norah Essali, Hugh Myrick, and Andrew J. Saxon

Introduction

Medications to treat co-occurring psychiatric symptoms or disorders in patients with alcohol use disorder

Summary and conclusions

MEDICATIONS USED TO REDUCE OR STOP DRINKING

Opioidergic Agents

Naltrexone

Clinical Considerations in the Use of Naltrexone

Nalmefene

SUMMARY

Acamprosate

Clinical Considerations in the Use of Acamprosate

Studies Comparing Acamprosate With Naltrexone and the Two Medications Combined

Alcohol-Sensitizing Agents

Pharmacology and Clinical Use of Disulfiram

GABAergic Agents

Topiramate

Gabapentin and Pregabalin

Baclofen

Serotonergic Agents

Psychedelics

Alpha Adrenergic Antagonists

Other Agents

N-acetylcysteine

MEDICATIONS TO TREAT CO-OCCURRING PSYCHIATRIC SYMPTOMS OR DISORDERS IN PATIENTS WITH ALCOHOL USE DISORDER

Antidepressant Treatment of Unipolar Depression and Alcohol Use Disorder

Mood Stabilizer Treatment of Bipolar Disorder and Alcohol Use Disorder

Treatment of Co-occurring Anxiety Disorders and Alcohol Use Disorder

UTILIZATION OF PHARMACOTHERAPY IN THE TREATMENT OF ALCOHOL USE DISORDER

SUMMARY AND CONCLUSIONS

Endocrine Disorders

NCM 116: CARE OF CLIENTS WITH NEUROLOGIC DISORDERS (ALTERATION IN PERCEPTION)

Fish Diseases and Their Management in Aquaculture

Anesthesia for Vascular Surgery

Management of Patient with Neurologic Dysfunction