Basic Biomedical Sciences I Case One: "Do I need a CBC?"

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Basic Biomedical Sciences I Case One: "Do I need a CBC?" Block Four Module One

BLOOD

· Blood is a tissue composed of red blood cells, white blood cells, and platelets suspended in a fluid blood plasma which also contains an immense number of ions, inorganic molecules, and organic molecules including plasma proteins.

· Average human possesses: five liters of blood.

HEMATOPOIESIS DEFINITION

· Hematopoiesis is defined as the production, development, differentiation, and maturation of all blood cells.

DIFFERENTIATION AS TO SITE OF PRODUCTION BEFORE AND AFTER BIRTH

DIFFERENTIATION BETWEEN INTRAMEDULLARY AND EXTRAMEDULLARY HEMATOPOIESIS

MECHANISM OF PRODUCTION AND RELEASE

ERYTHROCYTIC, RED CELL SERIES GENERAL DESCRIPTION

FUNCTIONS

Basophilic Normoblast, Prorubricyte

Polychromatophilic Normoblast, Rubricyte

Orthochromaphilic Normoblast, Metarubricyte

Reticulocyte

Mature Erythrocyte

LEUKOCYTIC (WHITE CELL) SERIES GENERAL DESCRIPTION

GRANULOCYTES (NEUTROPHILS, EOSINOPHILS, BASOPHILS)

Neutrophils

· Morphology:

. General Description

o Primary Granules

o Secondary Granules

· Functions

Eosinophils

. Morphology

· Functions

Basophils

· Morphology

· Functions

Two. some delayed hypersensitivity reactions

AGRANULOCYTES (MONOCYTES, MACROPHAGES, LYMPHOCYTES)

· General Descriptions

· Morphology

· Functions

Two. antigen processing

Four. synthesis of bioactive molecules

· General description

· Morphology

Platelets

· Functions of Platelets:

COMPLETE BLOOD COUNT DEFINITION

COMPONENTS

· White Blood Cell (WBC) Differential Count

· Red Cell Count (RBC)

· Hemoglobin (Hb)

· Hematocrit (Hct)

· Mean Corpuscular Volume (MCU)

· Mean Corpuscular Hemoglobin

O is the average concentration of hemoglobin in a given volume of red cells.

O is a measurement of the variability of red cell size and shape. Higher numbers indicate greater variation in size.

The number of platelets in a specified volume of blood. Circle.

SIGNIFICANCE OF ABNORMAL VALUES

White Blood Cell Counts

White Blood Cell Differential Count

Total W B C, white blood cell count:

Relative versus Absolute Values

The Neutrophils

Mechanisms: The primary factors influencing the neutrophil count are:

Neutropenia:

Mechanisms by which neutropenia occur include:

Eosinophilia

Causes of eosinophilia:

Monocytosis. Causes:

Platelets

HEMOGLOBIN

PORPHYRIN

BIOSYNTHESIS OF HEME

Overview

The text explores the process of hematopoiesis, detailing the production, maturation, and differentiation of blood cells from embryonic stages through adulthood. It highlights key organs involved, the types of cells produced, and the physiological mechanisms regulating blood cell development.

Key Points

1Hematopoiesis occurs in various organs throughout fetal and adult life
2Key organs involved include the bone marrow, liver, and spleen
3Erythropoietin plays a crucial role in red blood cell production
4Differentiation of blood cells is influenced by various growth and differentiation inducers
5The document discusses the different types of leukocytes and their maturation processes.

Details

Category: Health and Medicine

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