Host Pathogen Interaction of ESKAPE Pathogens

Host Pathogen Interaction of ESKAPE Pathogens

Abstract

The ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) poses a serious threat to global health since they are drug-resistant and can interact effectively with the host. This comprehensive report examines how ESKAPE pathogens resist the immune system by describing their methods of causing serious illness, developing drug resistance, and evading host defenses. By studying recent literature, this research clarifies the steps taken by pathogens in adhesion, colonization, biofilm formation, and immune system evasion. The research demonstrates that ESKAPE pathogens survive and grow in the host by forming biofilms, persisting inside immune cells, and escaping immune detection. The rapid development of resistance genes and the restrictions of traditional antibiotic use complicate current therapies. Anti-virulence strategies, host health interventions, and biotechnology-based therapies may address the challenges posed by these hospital-acquired infections. The information in this review highlights the essential features of ESKAPE infections and identifies urgent areas where further research is needed to address them.

Pathogenicity of ESKAPE Pathogen

One. Introduction