The Gastrointestinal Tract The gastrointestinal tract includ

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The Gastrointestinal Tract

The Gastrointestinal Tract

The gastrointestinal tract includes the organs through which food passes, together with associated exocrine glands. Its main structures are: Mouth Oesophagus Stomach Small intestine: Duodenum Jejunum Ileum Large intestine: Caecum Colon Rectum Anus

The associated glands and organs include the salivary glands, liver, gallbladder, and pancreas.

Conditions treated with gastrointestinal agents

Conditions treated with gastrointestinal agents

Gastrointestinal medicines are used in the treatment of:

Gastric acidity and hyperacidity

Gastritis Peptic ulcers

Gastro-oesophageal reflux disease, or GERD Bowel-motility disorders

Gastroparesis, which is delayed gastric emptying caused by partial paralysis of the stomach muscles Constipation

Diarrhoea

Nausea and vomiting

A patient with reflux may experience the movement of gastric juice from the stomach into the oesophagus. Symptoms may be reduced by avoiding lying down immediately after meals and by using a reclined or elevated bed position.

Peptic-ulcer occurrence may be associated with emotional disposition and stress. Management can include dietary control, antacids, anticholinergic therapy, bed rest, surgery in severe cases, and reducing stressful situations.

Main classes of inorganic gastrointestinal agents

Antacids Definition and purpose

Standards for an ideal antacid

Classification of Antacids

Sodium Bicarbonate USP

Reaction and adverse effects

Aluminium hydroxide USP

Aluminium hydroxide gel USP

Aluminium hydroxide gel is used as:

Calcium-Containing Antacids

Calcium carbonate USP

Properties

Reaction with hydrochloric acid

Uses and limitations

Tribasic calcium phosphate NF

Magnesium-Containing Antacids

Magnesium carbonate USP

Magnesium hydroxide USP

Milk of magnesia

Magnesium oxide has the formula magnesium oxide and a molar mass of approximately forty point three zero.

Light magnesium oxide

Reaction and uses

Adsorb pepsin Magnesium phosphate USP

Cathartics, Laxatives and Purgatives

Bismuth-containing antacids

Properties

Bismuth subnitrate is used:

Milk of bismuth USP

Composition and preparation

Kaolin USP

Occurrence and composition

Kaolin:

Uses and incompatibilities

Saline cathartics

Appropriate uses

Stimulant laxatives increase peristaltic activity by locally irritating the intestinal tract. Examples include:

Bulk-forming laxatives

Magnesium citrate USP

Non-official saline cathartics

Sodium sulfate

Preparation

Properties

Incompatibilities

Potassium phosphate

Properties and incompatibilities Potassium phosphate:

Potassium bitartrate

Properties

Calomel

Uses and action

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The Gastrointestinal Tract The gastrointestinal tract includ