Bibliometric Review
Bibliometric Review
Trends, advances, and emerging insights in hematopoietic stem-cell transplantation and viral-infection (nineteen eighty to twenty twenty-four) A bibliometric analysis
Abstract
Abstract
Background: Hematopoietic stem-cell transplantation (HSCT) is a cornerstone treatment for hematologic and autoimmune diseases, yet viral-infections remain a major complication affecting patient outcomes. This study aims to systematically map the research landscape of HSCT and viral-infections through bibliometric cluster and burst analyses, with the goal of identifying critical research hotspots and forecasting future directions for the field.
Methods: A literature search was conducted in the Web of Science Core Collection database, covering publications in the research fields of HSCT and viral-infections. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and the R package "bibliometric."
Results: This study included three thousand two hundred forty-seven publications, with the United States leading in output (one thousand two hundred thirty articles). Université Paris Cité was a prominent institution, contributing one hundred twelve publications. Blood was the most influential journal in the field, and Catherine M. Bollard was identified as a core author. Keyword cluster analysis revealed four main thematic clusters: clinical outcomes and risk management, basic science and mechanisms, immune response and immunotherapy, and viral detection and monitoring. Citation burst analysis indicated that recent research hotspots include "reactivation," "management," "mortality," "risk," "prevention," and "impact."
Conclusion: This bibliometric study elucidates the dynamic evolution of research on HSCT and viral-infections, which has shifted from fundamental immunological mechanisms to patient-centered strategies emphasizing risk assessment, early diagnosis, and personalized management. Keyword clustering and emerging citation bursts provide evidence-based insights into future research priorities, underscoring the critical role of advanced monitoring, precision immunotherapy, and targeted prevention in optimizing long-term HSCT outcomes.