Trends, advances, and emerging insights in hematopoietic stem-cell transplantation and viral-infection (1980 to 2024): A bibliometric analysis

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Bibliometric Review

Trends, advances, and emerging insights in hematopoietic stem-cell transplantation and viral-infection (nineteen eighty to twenty twenty-four) A bibliometric analysis

Abstract

Background: Hematopoietic stem-cell transplantation (HSCT) is a cornerstone treatment for hematologic and autoimmune diseases, yet viral-infections remain a major complication affecting patient outcomes. This study aims to systematically map the research landscape of HSCT and viral-infections through bibliometric cluster and burst analyses, with the goal of identifying critical research hotspots and forecasting future directions for the field.

Methods: A literature search was conducted in the Web of Science Core Collection database, covering publications in the research fields of HSCT and viral-infections. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and the R package "bibliometric."

Results: This study included three thousand two hundred forty-seven publications, with the United States leading in output (one thousand two hundred thirty articles). Université Paris Cité was a prominent institution, contributing one hundred twelve publications. Blood was the most influential journal in the field, and Catherine M. Bollard was identified as a core author. Keyword cluster analysis revealed four main thematic clusters: clinical outcomes and risk management, basic science and mechanisms, immune response and immunotherapy, and viral detection and monitoring. Citation burst analysis indicated that recent research hotspots include "reactivation," "management," "mortality," "risk," "prevention," and "impact."

Conclusion: This bibliometric study elucidates the dynamic evolution of research on HSCT and viral-infections, which has shifted from fundamental immunological mechanisms to patient-centered strategies emphasizing risk assessment, early diagnosis, and personalized management. Keyword clustering and emerging citation bursts provide evidence-based insights into future research priorities, underscoring the critical role of advanced monitoring, precision immunotherapy, and targeted prevention in optimizing long-term HSCT outcomes.

One. Introduction

Two. Materials and methods

Two point two. Statistical analysis and visualization

Three. Results

Three point two. Analysis of countries

Three point three. Analysis of institutions

Identification

Three point four. Analysis of Journals

Three point five. Analysis of authors

Three point six. Keywords co-occurrence analysis

Three point seven. Keyword burst analysis

Four. Discussion

Four point one. Research hotspots and frontiers

Four point two. Cluster one: clinical outcomes and risk management

Bibliometric indicators of high-impact journals.

Four point three. Cluster two: basic science and mechanisms

Four point four. Cluster three: immune response and immunotherapy

Four point five. Cluster four: viral detection and monitoring

Publication and citation profiles of high-impact authors.

infection control towards holistic, multidisciplinary strategies that address the multifactorial nature of posttransplant complications. The management of late viral reactivation and its consequences, such as increased relapse risk and non-relapse mortality in diseases like AML, has become a central research

Four point six. Strengths and limitations

Five. Conclusion

Overview

The study provides an extensive overview of research trends in HSCT and viral infections from 1980 to 2024. Through bibliometric methods, it highlights emerging themes, influential authors, and significant publications, offering insights into the shifting focus of research in this area.

Key Points

1Hematopoietic stem-cell transplantation remains crucial for treating hematologic diseases despite viral infection complications
2The study includes over 3,200 publications, emphasizing the USA as a leader in HSCT research
3Major thematic clusters have emerged around clinical outcomes, mechanisms of infection, and patient-centered strategies
4Citation burst analysis reveals pressing research areas such as reactivation and prevention of viral infections
5The findings underscore the need for advanced monitoring and targeted prevention strategies in HSCT.

Details

Authors: Minjing Mao, Jiacheng Zhu, Gang Cai, Jun Meng
Category: Health and Medicine

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