WOUND REPAIR
WOUND REPAIR
Physical includes incision or crushing extremes of temperature or irradiation, desiccation and obstruction of arterial inflow or venous outflow.
Chemical includes unphysiologic pH or tonicity, those that disrupt protein integrity, and those that cause ischemia.
EPITHELIZATION
EPITHELIZATION
Injured epithelium has genetically programmed regenerative ability that allows it to re-establish its integrity through proliferation, migration and a process known as contact inhibition.
Contact inhibition happens when a free edge of normal epithelium ceases to migrate if it comes into contact with another free edge of epithelium.
It begins the moment tissue injury occurs, lasts for three to five days.
Has two phases:
Vascular Phase
Cellular Phase
Also referred to as the Lag Phase because it is in this period that No Significant Gain in Wound Strength Occurs.