Beyond the Whole-Genome Duplication: Phylogenetic Evidence for an Ancient Interspecies Hybridization in the Baker's Yeast Lineage

Summary

Whole-genome duplications have shaped the genomes of several vertebrate, plant, and fungal lineages. Earlier studies have focused on establishing when these events occurred and on elucidating their functional and evolutionary consequences, but we still lack sufficient understanding of how genome duplications first originated. We used phylogenomics to study the ancient genome duplication occurred in the yeast Saccharomyces cerevisiae lineage and found compelling evidence for the existence of a contemporaneous interspecies hybridization. We propose that the genome doubling was a direct consequence of this hybridization and that it served to provide stability to the recently formed allopolyploid. This scenario provides a mechanism for the origin of this ancient duplication and the lineage that originated from it and brings a new perspective to the interpretation of the origin and consequences of whole-genome duplications.

Key Points

• 1The research provides evidence for an ancient hybridization event in yeast affecting genome stability
• 2Whole-genome duplications have significant evolutionary impacts across multiple species
• 3Phylogenomic analysis reveals complex histories of genome duplications and hybridizations
• 4The study contributes new perspectives on the origins of genome duplications in eukaryotes
• 5Findings suggest that interspecies hybridization can enhance the adaptability of newly formed polyploids.

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